![]() ![]() ![]() ![]() SAM-e can be used alone or in conjunction with other antidepressants. SAM-e appears to be an effective treatment for depression: Five of seven sources agree, and the two others say it's promising. It is available without a prescription in the United States and some other countries. SAM-e has been approved as a prescription drug for depression in Germany, Italy, Spain, and Russia, and has been in use in Europe for over three decades. S-adenosyl-L-methionine (commonly called "SAM-e") is a naturally-occurring chemical component present in all cells of the body where it is essential in more than 200 metabolic pathways. ![]()
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